Marie Curie grant to two promising CPR postdocs

Postdocs Teresa Lai Fong Ho and Dimitris Typas from the Mailand group at CPR have both received a Marie Skłodowska-Curie Individual Fellowships of 200,000 Euro ~ DKR 1,5 million.

More about Teresa's project - Impact of replicative stress on DNA replication timing control:

The primary aim of this study is to investigate a novel role for a master regulator of the cellular response to replication stress, ATR, in controlling the cellular replication timing program and corresponding gene expression. The outcomes of the project can better inform exploitation of replication stress in cancer therapeutics in the form of ATR inhibitors and underlying pathologies in ATR-deficient Seckel syndrome and associated hereditary diseases.

More about Dimitris project - Chromatin Study of DNA Double Strand Breaks

To keep chromosomal DNA intact and to prevent the onset of pathological conditions, such as cancer and premature ageing, cells have evolved appropriate protective mechanisms, collectively referred to as the DNA Damage Response (DDR).  Dimitris will select, validate and functionally characterise novel factors implicated in the branch of DDR called DNA double-strand breaks (DSBs) response in the context of specific chromatin environments, namely heterochromatin and euchromatin.