Novo Nordisk Foundation
Center for Protein Research

2013

Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry

High-resolution quantitative mass spectrometry has been used by Associate Professor, Michael Lund Nielsen's research team at Novo Nordisk Foundation Center for Protein Research to map phosphoinositide (PIP) interacting…

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Scientists show how cells protect their DNA from catastrophic damage A research team led by Professor Jiri Lukas from the Novo Nordisk Foundation Center at the University of Copenhagen has unveiled a profound biological…

A chromatin scaffold links nuclear architecture to the DNA damage response

Professor Jiri Lukas and his staff from the Chromosome Stability and Dynamics Group at CPR shows how SAFB1 dynamically relocalizes to damaged chromatin and helps to guard cells against genotoxic stress

Identifying poly(ADP-ribosyl)ation targets during genotoxic stress

Associate Professor Nielsen´s research team in the Department of Proteomics, in collaboration with the Chromosome Stability and Dynamics Group at CPR and international partners, made use of functional proteomics to…

Plk1-interacting Checkpoint Helicase Acts as a DNA Tension Sensor

Using a combination of microfluidics, fluorescence microscopy, and optical tweezers, scientists from the Center for Protein Research, Center for Healthy Ageing (Ian Hickson Lab), Biozentrum (University of Basel) and the…

A molecular switch underlying FGF receptor responses

Fibroblast Growth Factors (FGFs) control key cellular processes during early organ development and in adult life by activating members of the FGF receptor (FGFR) family. Deregulated FGFR signaling and trafficking have…

Acetyl-Phosphate is a Critical Determinant of Lysine Acetylation in E. coli

Professor Chuna Ram Choudhary and colleagues from his research group at Novo Nordisk Foundation Center for Protein Research uncover a critical role for acetyl-phosphate in bacterial acetylation. The study was published…

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

Researchers from Novo Nordisk Foundation Center for Protein Research in collaboration with Clinical researchers at the Centre for Chronic immunodeficiency (Freiburg, Germany) identify a hotspot for mutations in patients…

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

Researchers from Novo Nordisk Foundation Center for Protein Research find that correct regulation of polyubiquitin assembled through Met1 (Met1-Ub) plays a critical role in immune signalling elicited by bacterial…

Guarding against collateral damage during chromatin transactions

Matthias Altmeyer and Jiri Lukas from Novo Nordisk Foundation Center for Protein Research are featured in the latest edition of Cell with a ‘Leading Edge minireview’ on molecular guardians that limit chromatin…

Getting to the Heart of Signaling

CPR scientists identify the in-vivo Cardiac Targets of beta-Adrenergic Receptor Signaling by analyzing phosphoproteins from mice hearts treated with beta-blockers and activators