Early Holocene preservation differences between cortical and trabecular bone proteomes
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Early Holocene preservation differences between cortical and trabecular bone proteomes. / Ásmundsdóttir, Ragnheiður Diljá; Hansen, Jakob; Fagernäs, Zandra; Troché, Gaudry; Olsen, Jesper V.; Saña Seguí, Maria; Welker, Frido.
In: Journal of Archaeological Science: Reports, Vol. 57, 104643, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early Holocene preservation differences between cortical and trabecular bone proteomes
AU - Ásmundsdóttir, Ragnheiður Diljá
AU - Hansen, Jakob
AU - Fagernäs, Zandra
AU - Troché, Gaudry
AU - Olsen, Jesper V.
AU - Saña Seguí, Maria
AU - Welker, Frido
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Skeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simultaneously in many skeletal elements, including those recovered from archaeological sites. These two bone components are formed and maintained in different manners and at different rates. In palaeoproteomics there is currently no empirical data demonstrating differences in composition and/or preservation of cortical and trabecular bone proteomes. Here we analyse pairs of cortical and trabecular bone from six Early Holocene ungulate rib specimens from the site of La Draga, Spain, using shotgun proteomics. We observe generally larger proteomes, a larger number of peptides, and lower rates of degradation, for the cortical bone samples compared to the trabecular bone samples. These results suggest that in degraded proteomic contexts, preference should be given to the sampling of cortical bone in order to maximise the retrieval of larger and better-preserved bone proteomes.
AB - Skeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simultaneously in many skeletal elements, including those recovered from archaeological sites. These two bone components are formed and maintained in different manners and at different rates. In palaeoproteomics there is currently no empirical data demonstrating differences in composition and/or preservation of cortical and trabecular bone proteomes. Here we analyse pairs of cortical and trabecular bone from six Early Holocene ungulate rib specimens from the site of La Draga, Spain, using shotgun proteomics. We observe generally larger proteomes, a larger number of peptides, and lower rates of degradation, for the cortical bone samples compared to the trabecular bone samples. These results suggest that in degraded proteomic contexts, preference should be given to the sampling of cortical bone in order to maximise the retrieval of larger and better-preserved bone proteomes.
KW - Bone turnover
KW - Osteogenesis
KW - Palaeoproteomics
KW - Sampling ethics
KW - Shotgun proteomics
KW - Skeletal remains
KW - ZooMS
U2 - 10.1016/j.jasrep.2024.104643
DO - 10.1016/j.jasrep.2024.104643
M3 - Journal article
AN - SCOPUS:85196825979
VL - 57
JO - Journal of Archaeological Science: Reports
JF - Journal of Archaeological Science: Reports
SN - 2352-409X
M1 - 104643
ER -
ID: 397243002